The side effects of radiation depend on the treatment site. In most cases, the side effects will be limited to the area of the body receiving treatment. Most patients can expect mild to moderate fatigue which resolves within 4-6 weeks of completing treatment. Skin reaction consists of redness, itching, and dry peeling in many cases with the chance of a radiation burn (blistering or moist peeling of the skin) of less than 15% in most cases. Your doctor will describe expected side effects in your case based on your treatment type and area of the body receiving radiation treatments.