While Botox and Dysport help eliminate fine wrinkles, deeper wrinkles and folds often need more. One of the most common characteristics of a youthful look is volume. The loss of volume can give you a tired or upset look. In these situations, facial fillers are fantastic options of restoring lost volume in those areas where it is most noticeable. These fillers are injected directly into the area and are very well-tolerated. Depending on the type of filler used, results can last as long as 18 months per treatment. The most commonly treated areas are frown lines between the nose and upper lip (nasolabial folds), the tear trough underneath the eyes, and the cheekbones. Depending on the target area, potential fillers that may be used include Restylane, Perlane, Juvederm and Radiesse.